Takahashi K, Yamanaka S. Induction of pluripotent stem cells from mouse embryonic and adult fibroblast cultures by defined factors. Cell. 2006 Aug 25;126(4):663-76. doi: 10.1016/j.cell.2006.07.024. Epub 2006 Aug 10. PMID: 16904174.

• The Yamanaka paper, widely recognized for its groundbreaking discovery in reprogramming mature cells into pluripotent stem cells using four specific genes (Oct3/4, Sox2, Klf4, and c-Myc), has significantly impacted regenerative medicine and cell biology. This discovery has opened up new avenues for disease modeling, drug discovery, and potential cell-based therapies.

Mizushima N, Ohsumi Y, Yoshimori T. Autophagosome formation in mammalian cells. Cell Struct Funct. 2002 Dec;27(6):421-9. doi: 10.1247/csf.27.421. PMID: 12576635.

• This groundbreaking work by Ohsumi has provided significant insights into the mechanisms of autophagy, a cellular process vital for clearing damaged cellular components and essential for cellular health and longevity. His research has been instrumental in understanding the biological mechanisms that contribute to aging and diseases related to cellular degradation.